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Phosphorylation of the E2F-1-DP-1 heterodimer by cyclin B-dependent kinases, however, did not result in down-regulation of its DNA-binding activity, as is readily seen after phosphorylation by cyclin A-dependent kinases, suggesting that phosphorylation per se is not sufficient to regulate E2F DNA-binding activity. Depending on the pH of the growth medium, the yeast Yarrowia lipolytica secretes both an acidic proteinase and an alkaline proteinase, the synthesis of which is also controlled by carbon, nitrogen, and sulfur availability, as well as by the presence of extracellular proteins.


  • Trump lays into the Federal Reserve, says he’s ‘not thrilled’ about interest rate hikes
  • Update Thursday–Gold drops sharply on weak Chinese yuan fix
  • Some speculation on yesterday’s sell-off in the gold market
  • Gold at one-year low and a record number of investors in survey say it’s a buy
  • Gold’s seasonality. . The best time to buy gold is when everything is quiet.

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