Progesterone is produced from cholesterol with pregnenolone as a metabolic intermediate . In the first step in the steroidogenic pathway , cholesterol is converted into pregnenolone, which serves as the precursor to the progestogens progesterone and 17α-hydroxyprogesterone. These progestogens, along with another steroid, 17α-hydroxypregnenolone , are the precursors of all other endogenous steroids, including the androgens, estrogens, glucocorticoids, mineralocorticoids, and neurosteroids. Thus, many tissues producing steroids, including the adrenal glands , testes , and ovaries , produce progestogens.
DOC's primary purpose is to regulate electrolytes. However, it has other effects, such as to remove potassium from leucocytes  and muscle,  depress glycogen formation  and to stimulate copper containing lysyl oxidase enzyme  and connective tissue,  which attributes may be used by the body to help survive during potassium wasting intestinal diseases.  The greater efficiency of DOC in permitting sodium excretion (or perhaps it should be expressed as inefficiency at retention) must be partly through morphological changes in the kidney cells because escape from DOC's sodium retention takes several days to materialize, and when it does, these cells are much more efficient at unloading sodium if sodium is then added than cells accustomed to a prior low intake. Thus, paradoxically, a low salt intake should be protective against loss of sodium in perspiration.