The actual cause of depression is not yet clear. However, doctors and scientists believe that it is a result of an imbalance in the chemicals signaling the brain. Studies are ongoing to identify the imbalance and the signaling chemicals. Various illnesses and some adverse life situations may spark depression. However, a majority of men with lower testosterone levels also exhibits depression signs. Most of them are obese or overweight. It points out the relation between depression and body fat. Average testosterone levels may reverse the situation for men.
Drug abuse is intentional non-therapeutic use of a drug, even once, for its rewarding psychological and physiological effects. Abuse and misuse of Testosterone are seen in male and female adults and adolescents. Testosterone, often in combination with other anabolic androgenic steroids (AAS), and not obtained by prescription through a pharmacy, may be abused by athletes and bodybuilders. There have been reports of misuse by men taking higher doses of legally obtained Testosterone than prescribed and continuing Testosterone despite adverse events or against medical advice.