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The AR is important for therapeutic target in prostate cancer , thus many different inhibitors have been developed, primarily targeting the ligand binding domain of the protein, while inhibitors that target the N-terminal domain of the protein are still under development. [53] AR ligands can either be classified based on their structure ( steroidal or nonsteroidal ) or based on their ability to activate or inhibit transcription ( agonists or antagonists ). [54] Sulforaphane , a phytochemical derived from broccoli or the HSP90 inhibitor ganetespib or the NRF2 activator bardoxolone methyl has been shown to degrade both AR and AR-V7 and thus enhance the efficacy of antagonists like enzalutamide. [55] [56]

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