Testosterone has been subject to abuse, typically at doses higher than recommended for approved indication and in combination with other anabolic androgenic steroids; anabolic androgenic steroid abuse can lead to serious cardiovascular and psychiatric adverse reactions; if testosterone abuse suspected, check serum testosterone concentrations to ensure they are within therapeutic range; consider possibility of testosterone and anabolic androgenic steroid abuse in suspected patients who present with serious cardiovascular or psychiatric adverse events
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Androgens stimulate protein synthesis in muscle, and they usually do not affect the overall synthesis in the organism. Androgens stimulate the production of red blood cells by synthesis and secretion stimulation of erythropoietin, direct stimulation of hematopoiesis in bone, marrow stimulation and inclusion of iron ions in the red blood cells. Although the use of androgens causes a significant increase in hematocrit and hemoglobin levels. At the same time in healthy men, when testosterone enanthate is applied in amounts of 200 mg per week, during 16 weeks cycle, the significant increase in the number of red blood cells and the increase in the hematocrit and hemoglobin were observed.